Lymphocyte Trafficking in Inflammatory Bowel Disease

G&H  What is the current understanding of the role of lymphocyte trafficking in the pathogenesis of inflammatory bowel disease? BF  In the past, it was believed […]

Perianal Fistulas in Patients With Crohn’s Disease

G&H  What is the prevalence of perianal fistulas in patients who have Crohn’s disease? DS  Several studies throughout the world, including one that my colleagues and […]

Corticosteroid-Free Remission in Patients With Inflammatory Bowel Disease

G&H  Currently, when might corticosteroids be used in patients with inflammatory bowel disease? BS  Corticosteroids remain an important element in the treatment of inflammatory bowel disease […]

Reviewing Recommendations for Vaccines and Health Care Maintenance in Patients With Inflammatory Bowel Disease

G&H What are the current recommendations for influenza and respiratory syncytial virus vaccines in patients with inflammatory bowel disease? FF All patients with inflammatory bowel disease […]

Recent Research on Dietary Therapy for Patients With Crohn’s Disease

G&H  What is the current understanding of the role of diet in the pathogenesis of Crohn’s disease? JL  Diet is one of the potential environmental factors […]

Endoscopic Approaches to Crohn’s Disease Strictures

G&H  Prior to endoscopic intervention, which imaging modalities should be used for the evaluation of Crohn’s disease strictures? GK  In 2020, the Global Interventional Inflammatory Bowel […]

Exploring the Early-Life Microbiome and Future Risk of Inflammatory Bowel Disease 

G&H  What are the biggest early-life risk factors for inflammatory bowel disease overall? SN  Many studies have looked at risk factors for the development of inflammatory […]

Targeting Cytokines in Inflammatory Bowel Disease

G&H  How has the targeting of cytokines evolved in the treatment of inflammatory bowel disease?  MD  The first biologic that was introduced in the concept of […]

Choosing Among Small Molecule and Biologic Therapies for Patients With Ulcerative Colitis 

G&H  How do the small molecule and biologic therapies currently approved for ulcerative colitis differ in terms of mechanism of action and mode of administration? DH  […]

Using a Treat-to-Target Approach to Manage Patients With Inflammatory Bowel Disease 

G&H  What led to the concept of a treat-to-target approach for the management of patients with inflammatory bowel disease?  CS  Traditional management approaches to inflammatory bowel […]

Current Approach to Postoperative Crohn’s Disease

G&H  How common are endoscopic recurrence and clinical recurrence of Crohn’s disease following surgery? MR  The simple answer is that both are common. Endoscopic recurrence refers […]

Racial and Ethnic Disparities in Inflammatory Bowel Disease 

G&H  What are the prevalence and incidence rates of inflammatory bowel disease by race and ethnicity, and how have they changed? MB  The prevalence and incidence […]

When to Perform Fecal Diversion in Patients With Crohn’s Disease

G&H  What is the best choice for fecal diversion—an ileostomy or a colostomy—and how do these procedures compare?  JA  Typically, I favor an ileostomy over a […]

Transmural Healing in Inflammatory Bowel Disease

G&H  How can transmural healing be defined?  DR  Transmural healing refers to evidence of healing of all layers of the bowel, with the recognition that inflammation […]

Combining Mechanisms of Action to Treat Patients With Inflammatory Bowel Disease

G&H  What is the rationale for combining mechanisms of action to treat patients with inflammatory bowel disease?  SD  A therapeutic ceiling has been achieved in that […]

Using a Clinical Decision Support Tool for Inflammatory Bowel Disease

G&H  Why was there a need to develop a clinical decision support tool for inflammatory bowel disease?  PD  All of the US Food and Drug Administration […]

Artificial Intelligence in Inflammatory Bowel Disease

G&H  How can artificial intelligence be defined, and why is it being used in inflammatory bowel disease? RS  The colloquial concept of artificial intelligence (AI) represents […]

Vaccination Updates for Patients With Inflammatory Bowel Disease

G&H  Why are vaccinations important for patients with inflammatory bowel disease?  FF  As many as 70% of patients with inflammatory bowel disease (IBD) will be on […]

Histologic Healing in Inflammatory Bowel Disease

G&H  How can histologic healing be best defined in patients with inflammatory bowel disease? BC  This is a complex question to answer. Despite increasing evidence suggesting […]

Gastroduodenal and Jejunoileal Crohn’s Disease

G&H  How common are gastroduodenal and jejunoileal Crohn’s disease among the various types of Crohn’s disease? BC  Crohn’s disease can occur anywhere from the mouth to […]

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