Use of Interleukin-23 Inhibitors for the Treatment of Inflammatory Bowel Disease

G&H Why did interleukin-23 inhibition become a treatment approach for inflammatory bowel disease? EL There are several reasons. One is that overexpression of interleukin (IL)-23 has […]

Management of Patients With Refractory Ulcerative Proctitis

G&H What is the current understanding of the relationship between ulcerative proctitis and ulcerative colitis? MC Ulcerative proctitis is part of the disease spectrum of ulcerative […]

Use of Glucagon-Like Peptide-1 Receptor Agonists in Patients With Inflammatory Bowel Disease

G&H How prevalent are obesity and overweight in patients with inflammatory bowel disease, and how can these conditions affect this patient population? CB With the global […]

The Potential Role of Hyperbaric Oxygen Therapy in Patients With Inflammatory Bowel Disease

G&H Why has hyperbaric oxygen therapy been considered for the treatment of patients with inflammatory bowel disease? PD Inflammatory bowel disease (IBD), which encompasses both Crohn’s […]

Early Surgery for Patients With Ileal Crohn’s Disease

G&H Could you explain the concept of early surgery in ileal Crohn’s disease? GD Surgery has traditionally been used for the treatment of medically intractable disease […]

Inflammatory Bowel Disease and Cardiovascular Disease

G&H What studies have shown a link between inflammatory bowel disease and cardiovascular disease? RP Several epidemiologic studies have shown that inflammatory bowel disease (IBD) is […]

Pharmacoequity in Older Patients With Inflammatory Bowel Disease

G&H Currently, how common is inflammatory bowel disease in older adults? BK Inflammatory bowel disease (IBD) has traditionally been thought of as a disease of younger […]

Positioning Sphingosine-1 Phosphate Receptor Modulators in Inflammatory Bowel Disease

G&H What was the rationale for first considering sphingosine-1 phosphate receptor modulators as a treatment approach for inflammatory bowel disease? BS Biologic therapies have revolutionized the […]

Management of Patients With Mild Crohn’s Disease

G&H How can mild Crohn’s disease be defined? CH Mild Crohn’s disease can be described in terms of severity, which means the likelihood of progression over […]

Lymphocyte Trafficking in Inflammatory Bowel Disease

G&H What is the current understanding of the role of lymphocyte trafficking in the pathogenesis of inflammatory bowel disease? BF In the past, it was believed […]

Perianal Fistulas in Patients With Crohn’s Disease

G&H What is the prevalence of perianal fistulas in patients who have Crohn’s disease? DS Several studies throughout the world, including one that my colleagues and […]

Corticosteroid-Free Remission in Patients With Inflammatory Bowel Disease

G&H Currently, when might corticosteroids be used in patients with inflammatory bowel disease? BS Corticosteroids remain an important element in the treatment of inflammatory bowel disease […]

Reviewing Recommendations for Vaccines and Health Care Maintenance in Patients With Inflammatory Bowel Disease

G&H What are the current recommendations for influenza and respiratory syncytial virus vaccines in patients with inflammatory bowel disease? FF All patients with inflammatory bowel disease […]

Recent Research on Dietary Therapy for Patients With Crohn’s Disease

G&H What is the current understanding of the role of diet in the pathogenesis of Crohn’s disease? JL Diet is one of the potential environmental factors […]

Endoscopic Approaches to Crohn’s Disease Strictures

G&H Prior to endoscopic intervention, which imaging modalities should be used for the evaluation of Crohn’s disease strictures? GK In 2020, the Global Interventional Inflammatory Bowel […]

Exploring the Early-Life Microbiome and Future Risk of Inflammatory Bowel Disease

G&H What are the biggest early-life risk factors for inflammatory bowel disease overall? SN Many studies have looked at risk factors for the development of inflammatory […]

Targeting Cytokines in Inflammatory Bowel Disease

G&H How has the targeting of cytokines evolved in the treatment of inflammatory bowel disease? MD The first biologic that was introduced in the concept of […]

Choosing Among Small Molecule and Biologic Therapies for Patients With Ulcerative Colitis

G&H How do the small molecule and biologic therapies currently approved for ulcerative colitis differ in terms of mechanism of action and mode of administration? DH […]

Using a Treat-to-Target Approach to Manage Patients With Inflammatory Bowel Disease

G&H What led to the concept of a treat-to-target approach for the management of patients with inflammatory bowel disease? CS Traditional management approaches to inflammatory bowel […]

Current Approach to Postoperative Crohn’s Disease

G&H How common are endoscopic recurrence and clinical recurrence of Crohn’s disease following surgery? MR The simple answer is that both are common. Endoscopic recurrence refers […]