Combining Biologic Agents in Inflammatory Bowel Disease

G&H What is the rationale for combining biologic agents in inflammatory bowel disease? MA Most of the biologic agents that gastroenterologists are currently using are […]

Treatment De-Escalation in Patients With Inflammatory Bowel Disease

Abstract: Inflammatory bowel disease follows a relapsing and remitting course that can be augmented with the use of various pharmacologic therapies. Treatments used to induce […]

Update on Pregnancy in Patients With Inflammatory Bowel Disease

G&H What is the current understanding of the relationship between inflammatory bowel disease and fertility? AA Female patients whose inflammatory bowel disease (IBD) is under […]

The Expanding Role of Anti–IL-12 and/or Anti–IL-23 Antibodies in the Treatment of Inflammatory Bowel Disease

Abstract: The interleukin (IL)-12/IL-23 pathway is one of many proposed mechanistic pathways of intestinal inflammation. Earlier studies introduced IL-12 as a major cytokine in the […]

The Impact of Biologic Therapy on Outcomes of Inflammatory Bowel Disease Surgery

G&H Has the rate of inflammatory bowel disease surgery changed since biologic agents were introduced? EL The surgical rate has decreased with the advent of biologic […]

Implementing Dietary Modifications and Assessing Nutritional Adequacy of Diets for Inflammatory Bowel Disease

Abstract: Guidelines for dietary recommendations and nutritional therapy for patients with inflammatory bowel disease (IBD) are lacking, and patients are moving toward popular defined diets […]

Overview of Extraintestinal Manifestations of Inflammatory Bowel Disease

G&H What are the various types of extraintestinal manifestations associated with inflammatory bowel disease? ML There are a wide variety of extraintestinal manifestations. One category […]

Influence of Environmental Factors in the Development and Outcomes of Inflammatory Bowel Disease

Abstract: Inflammatory bowel disease (IBD), which mainly comprises Crohn’s disease (CD) and ulcerative colitis (UC), is a term for chronic inflammatory diseases of the gut […]

Irritable Bowel Syndrome and Dietary Interventions

Abstract: Irritable bowel syndrome (IBS) is the most prevalent functional gastrointestinal disorder, affecting approximately 14% of the global population. Symptoms of IBS are some of […]

The Role of Vitamin D in Elderly Inflammatory Bowel Disease Patients

Abstract: The role of vitamin D has long been discussed in many chronic diseases, and its significance in inflammatory bowel disease has recently gained attention. […]

Recent Research on Fecal Microbiota Transplantation in Inflammatory Bowel Disease Patients

G&H What is the current understanding of the role that the gut microbiome plays in inflammatory bowel disease? MF It is thought that bacterial and […]

Corrective Endoscopy for the Treatment of Structural Complications After Pouch Surgery

G&H When is pouch surgery indicated? BS Despite advances in medical therapy, approximately 20% of patients with ulcerative colitis (UC) eventually require colectomy for medically […]

The Development of Patient-Reported Outcome Measures in Inflammatory Bowel Disease

G&H What patient-reported outcome measures have traditionally been used in inflammatory bowel disease? PH To some extent, every patient visit involves a physician asking the patient […]

Complications Related to J-Pouch Surgery

Abstract: Restorative proctocolectomy with ileal pouch–anal anastomosis is the gold-standard surgical procedure for familial adenomatous polyposis, refractory ulcerative colitis, and colitis–associated dysplasia requiring colectomy. Numerous […]

Use of Medical Cannabis in Patients With Inflammatory Bowel Disease

G&H What is the current legal status of cannabis? JK As of March 2018, 9 US states have legalized cannabis (also known as marijuana) for […]

The Use of Mobile Applications in the Management of Patients With Inflammatory Bowel Disease

G&H Currently, how common is the use of mobile applications for managing inflammatory bowel disease? MH The use of mobile applications to manage inflammatory bowel […]

The Use of Complementary and Alternative Medicine in Patients With Inflammatory Bowel Disease

Abstract: Complementary and alternative medicine (CAM) includes products or medical practices that encompass herbal and dietary supplements, probiotics, traditional Chinese medicines, and a variety of […]

Inflammatory Bowel Disease in Travelers

G&H Why are inflammatory bowel disease patients at higher risk for infection, including opportunistic infection? GR The risk of infection is higher in patients with […]

Update on Fecal Microbiota Transplantation in Patients With Inflammatory Bowel Disease

G&H What is the rationale for using fecal microbiota transplantation to try to treat disease, particularly inflammatory bowel disease? PM The concept of using fecal […]

Safety and Positioning of Vedolizumab in Patients With Inflammatory Bowel Disease

G&H How safe is vedolizumab? What is its side-effect profile? BF Most drugs used to treat inflammatory bowel disease (IBD) are systemically immunosuppressive, which means […]