Antiviral Therapy in Elderly Patients With Hepatitis C Virus Infection

Justin Rheem, MD, Vinay Sundaram, MD, MSc, Sammy Saab, MD, MPH, AGAF, FAASLD

Gastroenterology & Hepatology

May 2015, Volume 11, Issue 5

 

Justin Rheem, MD, Vinay Sundaram, MD, MSc, and Sammy Saab, MD, MPH, AGAF, FAASLD

 

Dr Rheem is a resident in the Department of Medicine at Harbor-University of California at Los Angeles Medical Center in Torrance, California. Dr Sundaram is an assistant director in the Division of Hepatology at Cedars-Sinai Medical Center in Los Angeles, California. Dr Saab is a professor in the Department of Medicine and the Department of Surgery at the University of California at Los Angeles in Los Angeles, California.

 

Address correspondence to: Dr Sammy Saab, Pfleger Liver Institute, UCLA Medical Center, 200 Medical Plaza, Suite 214, Los Angeles, CA 90095, Tel: 310-206-6705, Fax: 310-206-4197, E-mail: SSaab@mednet.ucla.edu

 

Abstract: The emergence of direct-acting antiviral (DAA) agents has revolutionized the treatment schema for hepatitis C virus (HCV) infection. From cure rates to tolerability, DAA agents have shown outstanding profiles compared with the prior therapy of pegylated interferon with ribavirin. However, the efficacy and safety profiles of DAA therapy in older patients, particularly the elderly, have been unclear, and patients in the 1945 to 1965 birth cohort constitute the largest proportion of the HCV population in the United States. Treating elderly patients with pegylated interferon and ribavirin has been challenging due to the frequent presence of multiple comorbidities in the elderly and high discontinuation rates caused by adverse events. Now, as more DAA agents have become widely studied and approved, subgroup analyses for the elderly population are being elucidated. Analysis of the current literature shows that these agents have been effective, well tolerated, and safe in the elderly population. This article highlights the efficacy and safety differences in interferon-based therapy and interferon-free regimens for elderly patients with HCV infection.

 

Rates of hepatitis C virus (HCV) infection are disproportionately higher in older patients. In fact, patients born between 1945 and 1965 represent the highest proportion (70%) of HCV-infected individuals in the United States,1 and the prevalence of this birth cohort is estimated to be 3.5% according to the US National Health and Nutrition Examination Survey data.2 Compared with the younger population, the elderly population is more likely to be infected with HCV, with risk factors including male gender, non-Hispanic ethnicity, nonblack race, advanced age, and a history of blood transfusion before 1992.1 Some studies have defined elderly patients as those greater than 60 years of age, while other studies have used 65 years of age as the cutoff.1,3-6 Natural history models predict that the prevalence of HCV infection and its complications will increase through the next decade and will mostly affect people greater than 60 years of age.7

Achieving a sustained viral response (SVR) is associated with decreased liver-related complications and overall mortality in patients with advanced liver disease.8 Elderly patients are more likely than younger patients to have advanced liver disease (likely related concomitant liver conditions), increased duration of infection, and an increased rate of disease progression.9-12 Due to the increasing risk of cirrhosis13-15 and hepatocellular carcinoma development16,17 with advanced age, elderly patients are in special need of an effective antiviral treatment.

The standard of HCV therapy over the past decade has been pegylated interferon and ribavirin. However, many large clinical trials have excluded patients greater than 65 years of age, while other trials have reported high rates of discontinuation in elderly subgroups.18-21 Widespread use of pegylated interferon/ribavirin in clinical practice among elderly patients has been limited by the inherent adverse effects associated with this approach.22,23 Comorbidities such as coronary heart disease and diabetes are unfavorable factors for treatment response with pegylated interferon/ribavirin.20,24 In addition, adverse events and poor tolerability increase with age in pegylated interferon/ribavirin recipients.21 Thus, elderly patients as well as their physicians are often hesitant to initiate treatment with these agents.22,23,25

The availability of noninterferon, direct-acting antiviral (DAA) agents (Table 1) represents a major paradigm shift in the treatment of HCV infection.3,26,27 These therapies have been shown to achieve higher cure rates and improved side effect profiles in clinical trials. However, due to distinct characteristics of natural history as well as the presence of adverse events and comorbidities, antiviral treatment in elderly patients with HCV will continue to be challenging.

 

Interferon-Based Therapy

The combination of pegylated interferon and ribavirin has been the standard treatment for HCV infection. However, studies in elderly patients have been limited in comparison with those in the younger population.28,29 The impact of age in predicting SVR is debatable, but most studies suggest that SVR rates are lower among elderly patients infected with HCV genotype 1 who are treated with interferon-based therapy.30-42 For genotypes 2 and 3, the SVR rates have been similar regardless of whether the patients are elderly.30-33

The relatively low SVR rates in elderly patients are mainly caused by higher rates of virologic nonresponse to dual therapy.33-35 Higher rates of adverse effects, such as hemolytic anemia, have been seen in elderly patients.34,43-46 In addition, more concomitant comorbidities have been observed in elderly patients, particularly metabolic (P<.001)33 and cardiovascular (P<.001)33 disease, along with renal, pulmonary, and hematologic conditions that prevent the use of interferon and ribavirin.47 Dose modifications during HCV therapy are made more commonly in elderly than in younger patients.33,34,36 In multivariate regression analyses, advanced age was an independent risk factor for SVR rates.31,33,35,41,42 Elderly HCV patients have different clinical characteristics and treatment outcomes from younger patients and, thus, require special attention from their health care practitioners.

 

Protease Inhibitors 

The addition of the first DAA agents, boceprevir (Victrelis, Merck) and telaprevir (Incivek, Vertex), to pegylated interferon/ribavirin combination therapy was associated with higher SVR rates than the pegylated interferon/ribavirin regimen alone, but with more adverse effects. In fact, the manufacturing of telaprevir has been discontinued. There are very limited data on the stratification of SVR according to age in the United States. However, studies from Japan have shown similar SVR rates (69%-85.7%) in elderly patients who are infected with HCV genotype 1 compared with younger patients (82%-90.4%).48-50

Adverse effects are more common in elderly patients than in younger patients using telaprevir and boceprevir. For instance, severe anemia, rash, and a rise in creatinine level occur more frequently, leading to significantly greater rates of treatment discontinuation (33% in elderly patients vs 16% in young adults; P=.008).49

 

Polymerase Inhibitors

Although the SVR rates were not explicitly stratified between elderly and nonelderly patients treated with the combination of pegylated interferon/ribavirin and sofosbuvir (Sovaldi, Gilead), Lawitz and colleagues reported that the SVR rates were similar in patients 50 years of age and older (88%) and in patients less than 50 years of age (95%).3 In addition, according to the prescribing information for sofosbuvir, the SVR rates in patients greater than 65 years of age (n=90) have been similar to the SVR rates in younger patients.51

 

Interferon-Free Therapy

The sofosbuvir/ribavirin combination achieves high SVR rates in elderly patients. In a phase 3, open-label trial with 34 elderly subjects (age ≥65 years; 22% of 153 Japanese patients with HCV genotype 2), SVR was achieved in 96.7% of overall patients and 94.1% of elderly patients.52 Treatment-naive and treatment-experienced elderly subjects had SVR rates of 93.3% (14/15) and 94.7% (18/19), respectively. For subjects less than 65 years of age, SVR rates in treatment-naive and treatment-experienced arms were 98.7% (74/75) and 95.5% (42/44), respectively. A greater but not significantly higher incidence of adverse events was observed in elderly compared with younger subjects (76% and 72%, respectively), and the discontinuation rate was 0% in both groups. Elderly patients reported pruritus and anemia as the most common adverse events during treatment.

In the large multicenter trials with sofosbuvir/ribavirin, namely VALENCE, FUSION, FISSION, and POSITRON, subgroup analysis of SVR used age 50 years as the cutoff value, so conclusions on elderly patients cannot be drawn from these studies.3,26,27 Retrospective analysis of elderly patients from these studies may provide further support in treating HCV genotype 2 infection in elderly patients with sofosbuvir/ribavirin.

Data on treatment with sofosbuvir plus simeprevir (Olysio, Janssen) in elderly patients are limited. In the COSMOS trial, 8 out of 9 subjects age 65 years or older achieved SVR (88.8%). Stratification of adverse events was not performed according to age.53 Ledipasvir/sofosbuvir (Harvoni, Gilead) treatment has very promising SVR rates in elderly patients age 65 years and older (Table 2). Recently, Jacobson and colleagues reported a retrospective post hoc analysis of data in elderly patients (n=152) with genotype 1 HCV infection from 3 large phase 3 clinical trials: ION-1, ION-2, and ION-3.4,5,54,55 The SVR rates with ledipasvir/sofosbuvir combination therapy without ribavirin in elderly patients were 89% (17/19), 100% (40/40), and 97% (30/31) in 8-week, 12-week, and 24-week treatment periods, respectively; ledipasvir/sofosbuvir with ribavirin in elderly patients yielded SVR8, SVR12, and SVR24 rates of 92% (12/13), 97% (28/29), and 100% (20/20), respectively.

The 3D regimen (Viekira Pak, AbbVie)—which consists of paritaprevir (HCV NS3/4A protease inhibitor with ritonavir), ombitasvir (NS5A inhibitor), and dasabuvir (NS5B RNA polymerase inhibitor) with or without ribavirin—shows high efficacy and a strong safety profile in patients 65 years of age and older (Table 2). Flamm and colleagues presented an integrated safety and efficacy analysis of patients 65 years of age and older who received the 3D regimen.6,56-61 The SVR rate was 97.1%, including 98% in patients with compensated cirrhosis. The overall SVR rate with 3D with or without ribavirin among elderly patients with HCV genotype 1 in both treatment-naive and pegylated interferon/ribavirin–experienced patients was 97% (121/125). The overall adverse events were similar between the age groups; however, the frequency of adverse events was slightly higher for the older group among patients who received ribavirin compared with those who did not (93.9% vs 87.2%), and the majority of these events were mild to moderate in severity. Ribavirin dose modification occurred more frequently in older patients (16.5%) than in younger patients (7.0%). Discontinuation rates due to adverse events were infrequent and similar in younger (1.0%) and older (0.9%) patients.

 

Analysis and Future Directions

There are 3 all-oral DAA regimens currently approved by the US Food and Drug Administration for the treatment of chronic HCV infection (Table 3).62-64 This article highlights the efficacy and safety differences between interferon-based therapy and interferon-free regimens for elderly patients. Although interferon-based therapy reaches relatively high SVR rates in elderly patients, as compared with younger patients, higher adverse event rates in the elderly population with comorbidities can be a large barrier in completing the full course of therapy. In contrast, interferon-free regimens, regardless of the combinations, have consistently shown very promising cure rates with relatively low incidences of adverse events in the elderly population. Once regarded as a difficult-to-treat subgroup of HCV patients, the elderly population may have an exciting outlook in HCV therapy.

The SVR differences between nonelderly and elderly patients have diminished with the use of interferon-free DAA agents. There may be a number of reasons to explain lower SVR rates using interferon-based therapy. First, tolerability and thus adherence have been shown to decrease with advanced age.31-33,35-41 The risk of ribavirin-induced hemolytic anemia has been associated with advancing age.21,34,43-46 Second, hepatocytes appear to undergo a senescence process that blunts the interferon response.20,65-67 Specifically, chronic oxidative stress from excessive accumulation of vacuoles, lipofuscin, and lysosomes in the hepatocytes of elderly patients interferes with the cellular interferon response pathway.65-68

The results of a recent cost-effectiveness study have demonstrated the pharmacoeconomic advantages of treating HCV infection in elderly patients. Younossi and colleagues recently revealed the beneficial economic impact of treating patients born between 1945 and 1965 with interferon-free regimens.69 In the model, the interferon-free regimen was assumed to have a 98% SVR rate and cost $1000/day for 12 weeks. The researchers concluded that birth cohort screening and treating these patients without staging was a more cost-effective strategy, with an incremental cost-effectiveness ratio of $32,263 per quality-adjusted life-year (QALY), compared with a risk-based screening strategy. With highly efficacious and well-tolerated interferon-free regimens available, screening of the baby boomer birth cohort is highly cost-effective with great health and economic benefits at the population level.

In another model, Rein and colleagues estimated the clinical burden of HCV infection in Medicare costs as of 2009, and forecasted this burden until 2024 assuming 3 treatment strategies: no treatment, treatment with pegylated interferon/ribavirin and a protease inhibitor, and an all-oral DAA regimen.70 Of the cumulative 1,823,298 individuals with chronic HCV infection currently in Medicare or predicted to enter by 2024, treatment with pegylated interferon/ribavirin and a protease inhibitor and treatment with an all-oral DAA regimen reduced deaths by 29,720 and 126,163, respectively, and increased undiscounted QALYs by 1,562,119 and 7,692,906, respectively. Based on these significant improvements in terms of mortality and QALYs, treatment, especially with all-oral DAA regimens, could substantially reduce morbidity and mortality from HCV infection. Thus, antiviral therapy with DAA agents in the elderly population is cost-effective while mitigating the health consequences of HCV infection.

 

Summary

The current US Food and Drug Administration–approved, all-oral DAA regimens represent major advances in the treatment of elderly patients infected with HCV. Although these regimens are similar in their mode of action and efficacy rates, there may be important differences in drug interactions and duration of response that may favor one regimen over another. The elderly population represents a large percentage of HCV patients in the United States. The faster progression of advanced fibrosis and related complications associated with this age group, compared with younger individuals, underscores the need for treatment in this traditionally difficult-to-treat group. With their high efficacy rates and tolerability profiles, the new DAA agents can be used in elderly patients with HCV infection.

 

Dr Rheem does not have any relevant conflicts of interest to disclose. Dr Sundaram serves on the speakers bureaus and advisory boards of AbbVie, Janssen, and Gilead, and also serves on the speakers bureau for Salix. Dr Saab serves on the speakers bureaus of and is a consultant for AbbVie, BMS, Gilead, and Janssen.

 

References

1. Denniston MM, Jiles RB, Drobeniuc J, et al. Chronic hepatitis C virus infection in the United States, National Health and Nutrition Examination Survey 2003 to 2010. Ann Intern Med. 2014;160(5):293-300.

2. Ditah I, Ditah F, Devaki P, et al. The changing epidemiology of hepatitis C virus infection in the United States: National Health and Nutrition Examination Survey 2001 through 2010. J Hepatol. 2014;60(4):691-698.

3. Lawitz E, Mangia A, Wyles D, et al. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med. 2013;368(20):1878-1887.

4. Afdhal N, Zeuzem S, Kwo P, et al; ION-1 Investigators. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014;370(20):1889-1898.

5. Jacobson I, Kwo P, Kowdley K, et al. Virologic response rates to all oral fixed-dose combination ledipasvir/sofosbuvir regimens are similar in patients with and without traditional negative predictive factors in phase 3 clinical trials [AASLD abstract 1945]. Hepatology. 2014;60:1141A.

6. Flamm SL, Gane E, DuFour JF, et al. Safety of ABT-450/r/ombitasvir dasabuvir with or without ribavirin in HCV genotype 1-infected patients ≥65 years of age: results from phase 2 and 3 trials [AASLD abstract 1969]. Hepatology. 2014;60:1157A.

7. Davis GL, Alter MJ, El-Serag H, Poynard T, Jennings LW. Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression. Gastroenterology. 2010;138(2):513-521, 521.e1-6.

8. Bruno S, Battezzati PM, Bellati G, et al. Long-term beneficial effects in sustained responders to interferon-alfa therapy for chronic hepatitis C. J Hepatol. 2001;34(5):748-755.

9. Poynard T, Ratziu V, Benmanov Y, Di Martino V, Bedossa P, Opolon P. Fibrosis in patients with chronic hepatitis C: detection and significance. Semin Liver Dis. 2000;20(1):47-55.

10. Poynard T, Ratziu V, Charlotte F, Goodman Z, McHutchison J, Albrecht J. Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis C. J Hepatol. 2001;34(5):730-739.

11. Deuffic S, Buffat L, Poynard T, Valleron AJ. Modeling the hepatitis C virus epidemic in France. Hepatology. 1999;29(5):1596-1601.

12. Marcellin P, Asselah T, Boyer N. Fibrosis and disease progression in hepatitis C. Hepatology. 2002;36(5 suppl 1):S47-S56.

13. Minola E, Prati D, Suter F, et al. Age at infection affects the long-term outcome of transfusion-associated chronic hepatitis C. Blood. 2002;99(12):4588-4591.

14. Ohishi W, Kitamoto M, Aikata H, et al. Impact of aging on the development of hepatocellular carcinoma in patients with hepatitis C virus infection in Japan. Scand J Gastroenterol. 2003;38(8):894-900.

15. Tong MJ, el-Farra NS, Reikes AR, Co RL. Clinical outcomes after transfusion-associated hepatitis C. N Engl J Med. 1995;332(22):1463-1466.

16. Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol. 2009;27(9):1485-1491.

17. Davila JA, Morgan RO, Shaib Y, McGlynn KA, El-Serag HB. Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study. Gastroenterology. 2004;127(5):1372-1380.

18. Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet. 2001;358(9286):958-965.

19. Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med. 2002;347(13):975-982.

20. Hoofnagle JH, Seeff LB. Peginterferon and ribavirin for chronic hepatitis C. N Engl J Med. 2006;355(23):2444-2451.

21. Floreani A, Minola E, Carderi I, Ferrara F, Rizzotto ER, Baldo V. Are elderly patients poor candidates for pegylated interferon plus ribavirin in the treatment of chronic hepatitis C? J Am Geriatr Soc. 2006;54(3):549-550.

22. Gramenzi A, Conti F, Cammà C, et al; AISF HepaElder Study Group. Hepatitis C in the elderly: a multicentre cross-sectional study by the Italian Association for the Study of the Liver. Dig Liver Dis. 2012;44(8):674-680.

23. Tsui JI, Currie S, Shen H, Bini EJ, Brau N, Wright TL; VA HCV-001 Study Group. Treatment eligibility and outcomes in elderly patients with chronic hepatitis C: results from the VA HCV-001 Study. Dig Dis Sci. 2008;53(3):809-814.

24. Masarone M, Persico M. Antiviral therapy: why does it fail in HCV-related chronic hepatitis? Expert Rev Anti Infect Ther. 2011;9(5):535-543.

25. Thabut D, Le Calvez S, Thibault V, et al. Hepatitis C in 6,865 patients 65 yr or older: a severe and neglected curable disease? Am J Gastroenterol. 2006;101(6):
1260-1267.

26. Zeuzem S, Dusheiko GM, Salupere R, et al; VALENCE Investigators. Sofosbuvir and ribavirin in HCV genotypes 2 and 3. N Engl J Med. 2014;370(21):1993-2001.

27. Jacobson IM, Gordon SC, Kowdley KV, et al; POSITRON Study; FUSION Study. Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options. N Engl J Med. 2013;368(20):1867-1877.

28. Davis GL, Balart LA, Schiff ER, et al; Hepatitis Interventional Therapy Group. Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomized, controlled trial. N Engl J Med. 1989;321(22):1501-1506.

29. Di Bisceglie AM, Martin P, Kassianides C, et al. Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial. N Engl J Med. 1989;321(22):1506-1510.

30. Nishikawa H, Iguchi E, Koshikawa Y, et al. The effect of pegylated interferon-alpha2b and ribavirin combination therapy for chronic hepatitis C infection in elderly patients. BMC Res Notes. 2012;5:135.

31. Yu JW, Sun LJ, Kang P, Yan BZ, Zhao YH. Efficacy and factors influencing treatment with peginterferon alpha-2a and ribavirin in elderly patients with chronic hepatitis C. Hepatobiliary Pancreat Dis Int. 2012;11(2):185-192.

32. Aronsohn A, Ancuta I, Caruntu F, et al. Impact of age on viral kinetics of peginterferon alfa-2a/ribavirin in chronic hepatitis C: final analysis from the PROPHESYS cohort. J Viral Hepat. 2014;21(5):377-380.

33. Roeder C, Jordan S, Schulze Zur Wiesch J, et al. Age-related differences in response to peginterferon alfa-2a/ribavirin in patients with chronic hepatitis C infection. World J Gastroenterol. 2014;20(31):10984-10993.

34. Nudo CG, Wong P, Hilzenrat N, Deschênes M. Elderly patients are at greater risk of cytopenia during antiviral therapy for hepatitis C. Can J Gastroenterol. 2006;20(9):589-592.

35. Antonucci G, Longo MA, Angeletti C, et al. The effect of age on response to therapy with peginterferon alpha plus ribavirin in a cohort of patients with chronic HCV hepatitis including subjects older than 65 yr. Am J Gastroenterol. 2007;102(7):1383-1391.

36. Huang CF, Yang JF, Dai CY, et al. Efficacy and safety of pegylated interferon combined with ribavirin for the treatment of older patients with chronic hepatitis C. J Infect Dis. 2010;201(5):751-759.

37. Kainuma M, Furusyo N, Kajiwara E, et al; Kyushu University Liver Disease Study Group. Pegylated interferon α-2b plus ribavirin for older patients with chronic hepatitis C. World J Gastroenterol. 2010;16(35):4400-4409.

38. Honda T, Katano Y, Shimizu J, et al. Efficacy of peginterferon-alpha-2b plus ribavirin in patients aged 65 years and older with chronic hepatitis C. Liver Int. 2010;30(4):527-537.

39. Kim HI, Kim IH, Jeon BJ, et al. Treatment response and tolerability of pegylated interferon-α plus ribavirin combination therapy in elderly patients (≥65 years) with chronic hepatitis C in Korea. Hepat Mon. 2012;12(7):430-436.

40. Hu CC, Lin CL, Kuo YL, et al. Efficacy and safety of ribavirin plus pegylated interferon alfa in geriatric patients with chronic hepatitis C. Aliment Pharmacol Ther. 2013;37(1):81-90.

41. Oze T, Hiramatsu N, Yakushijin T, et al. Indications and limitations for aged patients with chronic hepatitis C in pegylated interferon alfa-2b plus ribavirin combination therapy. J Hepatol. 2011;54(4):604-611.

42. Frei P, Leucht AK, Held U, et al; Swiss Hepatitis C Cohort Study Group. Elderly age is not a negative predictive factor for virological response to therapy with pegylated interferon-α and ribavirin in chronic hepatitis C virus patients. Liver Int. 2014;34(4):551-557.

43. Saab S, Oh MK, Ibrahim AB, et al. Anemia in liver transplant recipients undergoing antiviral treatment for recurrent hepatitis C. Liver Transpl. 2007;13(7):1032-1038.

44. Takaki S, Tsubota A, Hosaka T, et al. Factors contributing to ribavirin dose reduction due to anemia during interferon alfa2b and ribavirin combination therapy for chronic hepatitis C. J Gastroenterol. 2004;39(7):668-673.

45. Nomura H, Tanimoto H, Kajiwara E, et al. Factors contributing to ribavirin-

nduced anemia. J Gastroenterol Hepatol. 2004;19(11):1312-1317.

46. Sulkowski MS. Anemia in the treatment of hepatitis C virus infection. Clin Infect Dis. 2003;37(suppl 4):S315-S322.

47. Kanwal F, Schnitzler MS, Bacon BR, Hoang T, Buchanan PM, Asch SM. Quality of care in patients with chronic hepatitis C virus infection: a cohort study. Ann Intern Med. 2010;153(4):231-239.

48. Furusyo N, Ogawa E, Nakamuta M, et al; Kyushu University Liver Disease Study (KULDS) Group. Telaprevir can be successfully and safely used to treat older patients with genotype 1b chronic hepatitis C. J Hepatol. 2013;59(2):205-212.

49. Fujino H, Imamura M, Nagaoki Y, et al; Hiroshima Liver Study Group. Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C. J Gastroenterol. 2014;49(12):1548-1556.

50. Takita M, Hagiwara S, Kudo M, et al. Efficacy and safety of telaprevir-based antiviral treatment for elderly patients with hepatitis C virus. Oncology. 2014;87(suppl 1):110-117.

51. Sovaldi [package insert]. Foster City, CA: Gilead Sciences Inc; 2014.

52. Omata M, Nishiguchi S, Ueno Y, et al. Sofosbuvir plus ribavirin in Japanese patients with chronic genotype 2 HCV infection: an open-label, phase 3 trial. J Viral Hepat. 2014;21(11):762-768.

53. Lawitz E, Sulkowski MS, Ghalib R, et al. Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study. Lancet. 2014;384(9956):1756-1765.

54. Afdhal N, Reddy KR, Nelson DR, et al; ION-2 Investigators. Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. N Engl J Med. 2014;370(16):1483-1493.

55. Kowdley KV, Gordon SC, Reddy KR, et al; ION-3 Investigators. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. N Engl J Med. 2014;370(20):1879-1888.

56. Kowdley KV, Lawitz E, Poordad F, et al. Phase 2b trial of interferon-free therapy for hepatitis C virus genotype 1. N Engl J Med. 2014;370(3):222-232.

57. Feld JJ, Kowdley KV, Coakley E, et al. Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med. 2014;370(17):1594-1603.

58. Zeuzem S, Jacobson IM, Baykal T, et al. Retreatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med. 2014;370(17):1604-1614.

59. Andreone P, Colombo MG, Enejosa JV, et al. ABT-450, ritonavir, ombitasvir, and dasabuvir achieves 97% and 100% sustained virologic response with or without ribavirin in treatment-experienced patients with HCV genotype 1b infection. Gastroenterology. 2014;147(2):359-365.e1.

60. Ferenci P, Bernstein D, Lalezari J, et al; PEARL-III Study; PEARL-IV Study. ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV. N Engl J Med. 2014;370(21):1983-1992.

61. Poordad F, Hezode C, Trinh R, et al. ABT-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis C with cirrhosis. N Engl J Med. 2014;370(21):1973-1982.

62. Harvoni [package insert]. Foster City, CA: Gilead Sciences Inc; 2014.

63. Olysio [package insert]. Latina, Italy: Janssen Therapeutics; 2013.

64. Viekira Pak [package insert]. North Chicago, IL: AbbVie Inc; 2014.

65. Tajiri K, Shimizu Y. Liver physiology and liver diseases in the elderly. World J Gastroenterol. 2013;19(46):8459-8467.

66. Feld JJ, Hoofnagle JH. Mechanism of action of interferon and ribavirin in treatment of hepatitis C. Nature. 2005;436(7053):967-972.

67. Chen L, Borozan I, Feld J, et al. Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection. Gastroenterology. 2005;128(5):1437-1444.

68. Schmucker DL. Age-related changes in liver structure and function: implications for disease? Exp Gerontol. 2005;40(8-9):650-659.

69. Younossi Z, Singer M, Henry L, et al. The use of all oral regimens for treatment of chronic hepatitis C (CHC) coupled with birth cohort screening is highly cost effective: the health and economic impact on the U.S. population [AASLD abstract 116]. Hepatology. 2014;60:256A.

70. Rein DB, Wittenborn JS, Liffmann D, Borton JM. Projected health and economic impact of hepatitis C on the United States Medicare system from 2010 to 2024 [AASLD abstract 73]. Hepatology. 2014;60:233A.

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