Vanessa C. Costilla, MD, Amy E. Foxx-Orenstein, DO, Anita P. Mayer, MD, and Michael D. Crowell, PhD
The authors are affiliated with the Mayo Clinic in Scottsdale, Arizona. Dr. Costilla is a Resident in the Department of Internal Medicine. Dr. Mayer is an Assistant Professor in the Division of Women’s Health Internal Medicine. Dr. Crowell is a Professor and Dr. Foxx-Orenstein is an Associate Professor in the Division of Gastroenterology.
Address correspondence to: Dr. Amy E. Foxx-Orenstein, Division of Gastroenterology, Mayo Clinic, 13400 East Shea Blvd, Scottsdale, AZ 85259; Tel: 480-301-6990; E-mail: Foxx-Orenstein.Amy@mayo.edu
Abstract: Fecal incontinence (FI) is a devastating disorder that is more prevalent than previously realized. FI is the involuntary loss of stool. Many factors contribute to the pathophysiology of FI, including advanced age, bowel irregularity, parity, and obesity. A detailed history and focused rectal examination are important to making the diagnosis and determining contributing causes. Although multiple diagnostic studies are available to assess the cause of FI, specific guidelines that delineate when testing should be done do not exist. Clinicians must weigh the risk, benefit, and burden of testing against the need for empiric treatment. All types of FI are initially managed in the same way, which includes lifestyle modification to reduce bowel derangements, improved access to toileting, and initiation of a bulking regimen to improve stool consistency. If initial conservative management fails, pharmacologic agents, biofeedback, or surgery may be indicated.
Fecal incontinence (FI) is a socially and emotionally devastating disorder that significantly affects the lives of patients and their families. Anal incontinence is the more general term, which refers to the involuntary loss of gas or stool. FI specifically refers to the involuntary loss of stool.1 FI is more common than previously thought, with a prevalence that varies by the population studied.2 Among institutionalized persons, prevalence has been reported to be as high as 45%.3 The prevalence of FI is similar between men and women at 7.7% and 8.9%, respectively, and increases with age, reaching 15.3% in persons age 70 years or older.4
Because of social stigma, many patients do not seek treatment, which suggests that prevalence in the general population is underestimated. In a self-reported survey, 36.5% of primary care patients reported episodes of FI, but only 2.7% of these patients had a documented diagnosis.5 Healthcare costs are 55% higher in patients with FI than continent patients,5 amounting to an estimated $11 billion annually.6
Primary care physicians, gastroenterologists, and gynecologists play a vital role in FI screening. Most patients can achieve significant improvement in symptoms through proper treatment. In addition, early diagnosis will prevent complications that can further reduce quality of life.
Pathophysiology
Bowel function and continence are controlled by multiple factors. Effective evacuation of fecal material involves a complex interaction of structural and sensory components within the anorectal unit and pelvic floor musculature.7 Structural components involved in defecation begin with the rectum, a muscular tube approximately 12–15 cm long terminating at the anus.
The sphincter of the anus is composed of 2 muscular components: the internal anal sphincter (IAS) and the external anal sphincter (EAS). The IAS comprises the smooth muscle component of the anal sphincter, providing up to 80% of the resting anal canal pressure.8 Smooth muscles of the IAS operate under involuntary control and are responsible for tonic activity that maintains the anal barrier at rest. Striated muscles of the EAS allow voluntary squeeze to further maintain continence. The puborectalis (PR) muscle, which forms a sling around the rectum, further augments these barriers. The PR is contracted at rest and maintains the anorectal angle at approximately 90˚. During defecation, this angle becomes obtuse, allowing for passage of stool. With voluntary squeeze, this angle becomes acute to ensure continence.
Stool arriving in the rectum results in rectal distension and a reflexive decrease in anal resting pressure, which allows fecal material sampling by the sensitive anoderm.1 An urge to defecate occurs based on the solid, liquid, or gas nature of the rectal contents. If the urge to defecate occurs at a socially inappropriate time, sympathetically mediated inhibition of rectal smooth muscle with voluntary squeeze of the EAS and PR occurs. Adequate rectal compliance is required for deferred defecation because the rectal contents are forced back into the rectal reservoir to await an acceptable time for defecation.7,9,10
FI results when continence mechanisms are compromised.11 Disorders that reduce stool consistency, weaken striated pelvic floor muscles or the IAS, impair sensation, alter colonic transit time or stool volume, or compromise cognitive functioning can all contribute to loss of continence.7 Subtypes of FI include passive incontinence, urge incontinence, and fecal seepage (Table 1).7,12
Risk Factors
Many factors contribute to impaired continence. These factors include liquid stool consistency, female sex, advanced age, multiparity, neurologic injury or disease, prior trauma, and poor general health (Table 2).13,14 Less known risk factors include obesity, smoking, chronic obstructive pulmonary disease, pregnancy, hysterectomy, urinary incontinence, and bariatric surgery.13,15-17 Diarrhea is by far the greatest risk factor for FI. One study found that women with diarrhea had an odds ratio of 53 (95% confidence interval, 6.1–471) of having inadvertent loss of stool.14 Rectal urgency with or without loose stools is a primary risk factor more than is obstetric injury.18
The incidence of FI increases significantly with age, attributed mostly to weak pelvic floor musculature and decreased anal resting tone. One study found anal resting tone decreased by approximately 0.5 mmHg per year and, in women, 3 mmHg per birth.19
Rectal sensation is not directly affected by age or parity.19 Parity is associated with frequent sphincter defects due to repetitive trauma during delivery. Evidence shows a relationship between pelvic floor disorders and operative or traumatic vaginal delivery.20,21 A method to determine which women are at greatest risk for FI does not exist, and current literature does not support a significant benefit of cesarean delivery over nontraumatic vaginal delivery for pelvic floor health or preserving anal continence.22,23 Advising cesarean section to prevent pelvic floor disorders is not recommended24 because pregnancy alone is considered a risk factor for incontinence.
Obesity is a risk factor for FI.25 FI has been reported to be nearly 50% more prevalent in obese women compared with women of normal weight.26,27 Although bariatric surgery is the most effective treatment for morbid obesity, post–bariatric surgery patients are also at significant risk for FI due to changes in stool consistency. Forty-eight percent of women and 42% of men post–bariatric surgery reported liquid stool incontinence, and 21% of women and 30% of men reported solid stool incontinence.16
In younger women, FI is strongly associated with functional bowel disorders, including irritable bowel syndrome (IBS), constipation, and diarrhea. In one study, 22% of patients with IBS reported at least occasional seepage and FI, attributable to deranged bowel habits.28
For both genders and across all age ranges, the causes of FI are manifold and may overlap. Many patients have sphincter injuries that remain asymptomatic for years until they experience age- or hormone-related changes, such as muscle or tissue atrophy, which then limit the ability to compensate for their remote injury.
Clinical Evaluation
A detailed history and focused rectal and neurologic examinations are important to making the diagnosis and determining potential contributing causes. The history should include an evaluation of medications and dietary habits that may alter bowel frequency and stool consistency. Obtaining a bowel diary can be helpful. It should include information on the number of episodes, product (gas, mucus, liquid, or solid), volume, stool consistency, ability to sense stool, urgency, straining, and feeling of constipation. Table 3 provides a checklist for questions that patients being evaluated for FI should be asked.29 Neurologic evaluation should assess cognition, strength, and gait.
The perineum should be inspected for moisture, skin irritation, feces, scars, anal asymmetry, fissures, and gaping of the sphincter. The presence of an anal wink and perineal sensation should be ascertained. Anal spasm can sometimes be identified visually. When bearing down briefly as if to evacuate, the degree of perineal descent and any bulging or prolapse from the rectum or vagina should be noted. Check for the presence of large or prolapsed hemorrhoids, as they can cause soiling.
A digital rectal examination is key for identifying anatomic abnormalities. Sharp, knifelike pain indicates active mucosal injury such as an acute or chronic fissure, ulcer related to injury, infection, or possible inflammatory bowel disease (IBD). Check for subtle anal spasms; lax or intense anal tone at rest and with bearing down provides potential clues to pelvic floor disorders.
Diagnostic Studies
Although multiple diagnostic studies assess the cause of FI, specific guidelines delineating when testing should be done do not exist. Clinicians must weigh the risk, benefit, and burden of testing against the need for empiric treatment. Consideration is given to a patient’s ability to participate in testing, comorbidities, and the potential diagnostic yield of the study.30 Diagnostic testing can aid in the following clinical scenarios:
1) suspected anal sphincter injury, 2) overflow incontinence versus sphincter injury, 3) suspicion of pelvic floor dysfunction, 4) noncorrelation of the history and examination, and 5) when testing could eliminate other causes of FI.
Endoanal Ultrasound
Endoanal ultrasound remains the standard for identifying anal sphincter injuries, including tears, scars, atrophy, and anal fistulae.31 It provides excellent resolution of the IAS but is less accurate with the EAS. EAS imaging is operator-dependent. Distinguishing the EAS from perirectal fat is challenging because both structures are echogenic.
Anorectal Manometry
Anorectal manometry systems quantify IAS and EAS function, rectal sensation, and compliance.1 The water-perfused probe is least expensive and traditionally used. Solid-state probes with closely spaced pressure sensors are becoming more common. High-resolution 3-D manometry with up to 256 sensors are now available to evaluate pressure profiles and topographic changes, which might increase diagnostic yields.1
Anorectal manometry should be performed in laboratories with experienced interpretive personnel. Anal resting and squeeze pressures and rectoanal inhibitory reflex should be measured. Anal resting and squeeze pressures are often low in FI, suggesting weak IASs and EASs, respectively. Other factors, such as watery stool or reduced sensation, may contribute to FI in patients with normal anal pressures. Figure 1 illustrates resting and squeeze pressures using high-resolution manometry.
The rectal balloon distention test measures rectal sensation and compliance by assessing sensory-motor responses to incremental volumes of air or water.32 Sensation may be normal, reduced, or increased in patients with FI. Reduced sensation may allow stool leakage before the EAS can contract. Patients with increased rectal sensation may have rectal hypersensitivity or reduced rectal capacity.9 Patients with reduced compliance or capacity experience rectal urgency and frequent defecation.
The balloon expulsion test can help identify, but does not exclude, a functional defecation disorder.31 A balloon is inflated with water to a fixed volume, usually 50 mL, inside the rectum. The patient is then seated on a commode and asked to expel the balloon. The test is normal if the patient expels the balloon within 60 seconds. This test is often used in screening for chronic constipation.
Standard Defecography and Pelvic Magnetic Resonance Imaging
Standard defecography provides dynamic evaluation of the pelvic floor and can indicate the presence of rectal prolapse, enterocele, rectocele, and cystocele.33 Oral liquid barium delineates the small intestine. Thick barium paste is inserted into the rectosigmoid, and then dynamic anatomy and pelvic floor motion images are recorded with the patient at rest, coughing, squeezing, and straining to expel the barium.31 Defecography is not standardized across institutions and is not widely available.
Dynamic pelvic magnetic resonance imaging (MRI) is the only imaging modality that can evaluate global pelvic floor anatomy as well as the anal sphincter without radiation exposure.34 This modality has played a key role in identifying mechanisms of difficult or complex bowel function. It is expensive and not widely available. Figure 2 compares standard defecography with dynamic pelvic MRI.
MRI of the anal sphincter provides superior spatial resolution of the IAS and EAS.30,34 The EAS can be distinguished from surrounding perirectal fat, allowing better diagnosis of EAS atrophy.9 However, MRI is costlier than defecography and not widely available.
Neurodiagnostic Studies
Anal electromyography may identify sphincter denervation, myopathic damage, neurogenic damage, or a mixed injury.31 Needle or surface electrodes may be used. However, mapping of sphincter defects is no longer recommended.35
Pudendal nerve terminal motor latency (PNTML) measures the muscular integrity between the terminal pudendal nerve and the anal sphincter,1 helping to determine whether sphincter weakness is due to pudendal nerve injury, sphincter injury, or both. PNTML was previously thought to identify patients likely to benefit from surgical repair of sphincter defects. Recent studies do not support this assertion, however,36 and the American Gastroenterological Association recommends against PNTML testing for evaluation of FI.32
Stool tests and intestinal transit studies may be used to explain the cause of a patient’s underlying diarrhea or constipation. Endoscopy may be necessary to diagnose diseases that exacerbate FI, such as IBD, celiac disease, or microscopic colitis. Ultimately, ascertaining the principal cause of the patient’s FI is essential because it will direct treatment strategies and affect clinical outcomes.
Management
All types of FI are initially managed in the same way. Management consists of lifestyle modification to improve bowel derangements, access to toileting, and initiation of a fiber regimen (Figure 3).
Lifestyle Modification
Lifestyle modification may improve FI. Patient education is important to help ensure adherence. Among other issues, medication use and diet should be examined. Polypharmacy is common, especially in older adults. Diarrhea is a common adverse effect of medications, with some causing loose stools or increased gastrointestinal motility. As such, medications that exacerbate FI, including over-the-counter herbs and vitamins, should be reviewed and adjusted.
A patient’s diet can be evaluated to elicit factors that exacerbate FI, including diets that are high in sugar and caffeine. Alternatively, a diet high in fiber may improve stool consistency and decrease episodes of FI and seepage. Dietary changes to prevent loose stool should be pursued.
Some studies show that daily exercise improves FI, while other studies suggest that exercise has no effect on the frequency of FI episodes.37 Nevertheless, physical therapy and exercise that improve patient mobility will improve toileting opportunities and toilet accessibility. Additionally, FI frequency decreases in obese patients who lose weight.25
The use of absorbent products is a common self-care practice for patients with FI. Few products are specifically designed to absorb fecal material. Patients report using a variety of products such as pads, panty-liners, and pull-up briefs, which are all originally designed for urine or menstrual leakage.38,39 Persons more likely to use these products include women, those reporting a higher FI severity score, and the elderly. Containment of anal leakage with the use of pads is problematic because of the odor produced and resultant skin conditions due to contact of the skin with fecal matter.40,41
Use of anal plugs is another option for patients with FI. Anal plugs come in different designs and sizes and are meant to block involuntary loss of stool.42,43 A Cochrane systematic review concluded that patient tolerance of the anal plug limits its usefulness; however, if tolerated, anal plugs are effective in preventing incontinence.44
Limited mobility contributes to FI, especially in elderly and physically impaired patients. Limited mobility may be alleviated by scheduled toileting and changes within the home to allow better toilet access. Examples include moving a patient’s sleeping area closer to a bathroom or providing a portable bedside commode. Furthermore, ensuring access to assist devices, including walkers and canes, may help patients get to a toilet in time.
Pharmacologic Therapy
Initial efforts should focus on modifying stool formation because formed stool is much easier to control than loose stool. Initiation of bulking agents such as methylcellulose, psyllium, or partially hydrolyzed guar gum is often effective. Pharmacotherapy for diarrhea with agents such as loperamide, diphenoxylate/atropine, alosetron (Lotronex, Prometheus), clonidine, cholestyramine, colestipol, probiotics, tincture of opium, and amitriptyline is usually reserved for patients with more refractory symptoms that do not respond to conservative therapies.45 Guidelines for the use of common antidiarrheal medications in FI are provided in Table 4.
Patients with diarrhea-predominant IBS require special consideration because fiber therapy may exacerbate abdominal pain and bloating, contributing to poor compliance. If these symptoms do not abate after 7 days, initiation of other pharmacotherapy, including loperamide, a tricyclic antidepressant, probiotics, or alosetron, may provide more effective relief for this subset of patients.46
Chronic constipation may lead to rectal distention resulting in a chronically enlarged rectum and altered rectal sensation. Increased rectal capacity and decreased rectal sensitivity can increase a patient’s risk of overflow incontinence. In taking a history, it is important to clarify the volume and consistency of fecal loss because overflow incontinence will most likely be associated with small volume, liquid, or soft stool loss without a preceding normal bowel movement. Overflow incontinence is particularly prevalent in elderly patients.
Once constipation has been identified as the underlying cause for the patient’s FI, an empiric trial of fiber therapy should be initiated. Although stool softeners such as docusate are often used in clinical practice, fiber should be the first line of therapy. A large study comparing the efficacy of psyllium with docusate found that psyllium was significantly superior to docusate in providing relief of constipation.47
Fiber should be initiated in low doses and titrated gradually to 25–30 g daily (including dietary fiber). Caution is advised when initiating fiber therapy in patients with IBS, as it may worsen symptoms of abdominal bloating and discomfort.
Additional pharmacologic agents should be reserved for patients not responding to or intolerant of conservative interventions. When recommending laxatives, the practitioner should take care not to stimulate excessive gas production that can contribute to flatal incontinence. Nonabsorbable sugars (eg, lactulose and sorbitol) draw water osmotically into the intestinal lumen, stimulate colonic motility, and can cause abdominal discomfort and flatulence. A review by Gallegos-Orozco and colleagues of agents useful in the treatment of constipation was published in 2012 in the American Journal of Gastroenterology.48
Fecal seepage is distinctly different from FI in that it usually involves the loss of small liquid or soft stool after a normal bowel movement.12,49 However, patients may report an abnormal bowel habit or symptoms more consistent with anal sphincter dysfunction, which may not be detected as a physiologic abnormality on objective anorectal testing. Seepage may be caused by hemorrhoids, poor hygiene, anal fistula, rectal prolapse, and hypo- or hypersensitivity of the rectum.
Interestingly, fecal seepage is more prevalent in men and patients with preserved anal sphincter and rectal function.49 In patients with fecal seepage, assessment and treatment of a specific cause may resolve symptoms. If symptoms persist, clearance of the rectal vault should be performed at regularly scheduled times each day, regardless of the urge to defecate. Clearance of the rectal vault can be attempted with enemas or suppositories. Tap water enemas are preferred for chronic usage because repeated application of sodium phosphate or glycerin (common components of over-the-counter enema and suppository preparations) may precipitate mucosal damage and result in rectal bleeding. Ideally, the designated time for routine clearance of the rectal vault should be within 30 minutes after a meal to maximize postprandial colonic reflexes. A variety of agents have been used to bulk the anal sphincter to provide a barrier, including silicone, carbon-coated beads, and dextranomer in hyaluronic acid. A Cochrane systematic review, published in 2010, was unable to draw definitive conclusions on the efficacy of injectable bulking agents due to the limited number of trials available.50 However, a systematic review published in 2011 found that use of silicone or ceramic microspheres of calcium hydroxylapatite was associated with greater success than other agents.51
Dextranomer in stabilized hyaluronic acid is the most recent agent to be studied and approved by the US Food and Drug Administration. It has been shown to reduce the number of FI episodes by more than 50% in over half of all patients studied.52,53 Adverse events from injectable bulking agents include anorectal pain, minor bleeding, or, rarely, rectal abscesses.
Nonpharmacologic Options
Nonpharmacologic options include biofeedback, sacral nerve stimulation (SNS), and surgery.
Biofeedback is a form of operant conditioning in which information about a physiologic process, which might otherwise be unconscious, is presented to a subject with the aim of having the subject modify that process consciously. For patients with FI, the process often involves physiologic monitoring of the striated pelvic floor muscles to facilitate directed strengthening exercises. Another method combines strengthening exercises with sensory discrimination training, consisting of brisk EAS contraction in response to rectal balloon distention.
Biofeedback has been advocated as first-line therapy for patients whose symptoms are mild to moderate. Although there is insufficient evidence with which to select patients suitable for anorectal biofeedback training, most experts agree that the appropriate patient for referral should have physiologic evidence of anal dysfunction, be able to cooperate, be well motivated, and possess some degree of perception of rectal distention and the ability to contract the EAS. Severe FI, pudendal neuropathy, and underlying neurologic problems have been associated with a suboptimal prognosis.54-56 A systematic review of randomized controlled trials found limited evidence supporting the clinical efficacy of biofeedback. However, the authors found few easily comparable well-designed studies available for review.55 A more recent Cochrane review of 21 trials supported the use of biofeedback in patients who had tried and failed other methods of treatment.57
SNS is a promising yet challenging treatment option for FI.58 Originally investigated as a method for paraplegic rehabilitation and return to ambulation, SNS was instead found to improve voiding.59 Subsequently, SNS was noted to have a positive effect on FI. Despite lack of understanding the underlying physiologic mechanism with which SNS acts to improve symptoms, its use in FI was first reported in 1995.60 Early reports showed success rates between 67% and 100%.61 These initial results led to broad popularity and rapid deployment in Europe.
A considerable advantage of SNS for FI is the ability to test for treatment efficacy with percutaneous nerve evaluation (PNE) prior to permanent implantation of the SNS system. PNE involves the percutaneous placement of an electrode through a sacral foramina to allow temporary stimulation of a sacral nerve, usually S3, with the goal of identifying patients who will benefit from permanent SNS placement.58
Long-term outcomes regarding the success of SNS beyond the original short-term results are beginning to emerge, with success rates of 54–92%. Parameters of success are variably reported to include reduced FI episodes, full continence, a perceived improvement in ability to defer defecation, improvement in Cleveland Clinic FI scores, resting and squeeze anal pressures, and other criteria.61-64
Long-term adverse event reports are limited in patients receiving SNS to treat FI. However, postoperative complications have been reported in up to 30% of elderly patients undergoing SNS for urinary symptoms.65 Complications include pain at the site of implant, pouch infection, sensation of electric shock, and, rarely, lead displacement or battery failure requiring reoperation. Failure rates of up to 25% and revision rates up to 50% have been reported in urologic disorders.66 One recent study of patients receiving SNS for FI found that 24% had surgical revisions.67
Surgery is indicated for patients whose FI is a consequence of a severe anatomic defect. Sphincteroplasty is the most common surgery, using either the overlapping sphincter repair or “end-to-end” repair technique. Overlapping sphincter repair has gained favor and is generally the first line of surgical intervention. Wound disruption leading to delayed healing occurs frequently. Although as many as 60% of patients report benefit from the operation,68 other studies suggest that long-term efficacy of overlapping sphincteroplasty is poor, with only 14% of patients remaining fully continent at 5 years.69 Patients who were older at the time of sphincteroplasty had worse long-term outcomes.70 In one systematic review, sphincteroplasty reduced FI, but no patients were completely continent after 10 years. Sustained improvements in health-related quality of life were reported; however, additional surgery for incontinence was performed in up to 18% of patients.71
Graciloplasty and gluteus maximus transposition are options that provide patients with a new biologic sphincter. These procedures are preferred in patients with severe sphincter damage in which sphincteroplasty would not suffice. In graciloplasty, the gracilis muscle is mobilized, and the distal tendon is divided. The muscle is wrapped around the anal canal.72 In dynamic graciloplasty, electrodes are attached to the muscle and connected to a neurostimulator that is implanted in the lower abdominal wall.73 Dynamic graciloplasty is done to improve the functionality of the transposed gracilis muscle. The overall success rate ranges from 52–62%.73-75 However, the complication rate of dynamic graciloplasty is high, with infection occurring in 25–28% of cases.76 Other complications include fecal evacuation problems, leg pain, bowel injury, perineal pain, and neoanal strictures.
Artificial anal sphincters may be an option in some patients. The artificial sphincter is placed around the native sphincter via perianal tunnels. The artificial sphincter remains inflated until the patient wishes to defecate, at which time the device is deactivated.68 The overall success was about 47–53% in the patients who were able to retain their device.77,78 Most patients required operative revisions, and 33% required device explantation.76 Other complications included infection, device erosion or malfunction, chronic pain, and obstructed defecation. Artificial anal sphincters should only be considered in patients with severe incontinence whose other options are limited.
A 2010 Cochrane review analyzed 11 trials comparing different surgical interventions. Given the limited number of trials and small sample sizes, it was not possible for the authors to recommend one type of surgical technique over another.79 Trials with larger sample sizes are needed for more definite recommendations. Colostomy or permanent stoma for FI is considered a reasonable option for patients who have failed or had poor response to multiple alternative treatments.
Conclusion
FI is a disabling disorder resulting in reduced physical, emotional, and social quality of life. A detailed evacuation history and anorectal examination are key to devising a focused diagnostic and effective, tiered treatment strategy for these patients. The majority of patients with FI can achieve marked improvements in quality of life with the simple measures that have been outlined in this review. Surgical interventions should be reserved for the rare patient, such as the patient with a clear anatomic defect, who cannot be managed with more conservative approaches.
The authors have no conflicts of interest to disclose.
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