The Role of Ultrasound in the Management of Inflammatory Bowel Disease

G&H What are the main applications of ultrasound in the management of inflammatory bowel disease? SW There are many applications, and they encompass every aspect of […]

Management of IBD Patients During the COVID-19 Pandemic

G&H Do patients with inflammatory bowel disease have a greater risk of becoming infected with coronavirus disease 2019? GL The best current estimates are that individual […]

Management of Inflammatory Bowel Disease With Telemedicine

G&H What are some of the forms of telemedicine that have been used in the management of inflammatory bowel disease? CS There are many different […]

Day-by-Day Management of the Inpatient With Moderate to Severe Inflammatory Bowel Disease

Abstract: Hospitalization for inflammatory bowel disease is common and requires coordination of care. The goals of hospitalization are to markedly improve symptoms, transition management to […]

Sexual Issues and Fertility in Male Patients With Inflammatory Bowel Disease

G&H What have studies shown regarding the association of inflammatory bowel disease and male sexual function? MH The impact of inflammatory bowel disease (IBD) on […]

Positioning Biologic Therapies in the Management of Pediatric Inflammatory Bowel Disease

Abstract: The incidence and prevalence of pediatric inflammatory bowel disease (IBD) are rising worldwide, with a steep increase in children under 5 years of age. […]

Clinical Implications of Recent Findings From the EVOLVE Study

G&H What is the EVOLVE study? BB The EVOLVE (Entyvio Outcomes in Real-World Bio-Naive Ulcerative Colitis and Crohn’s Disease Patients) study is a retrospective, multicenter, cohort […]

Impact of Obesity on the Management of Inflammatory Bowel Disease

Abstract: The worldwide prevalence of obesity has reached staggering proportions, and the inflammatory bowel disease (IBD) population has not been immune to this trend, with […]

Targeting Beta-7 Integrins for the Treatment of Inflammatory Bowel Disease

G&H How and why did targeting beta-7 integrins become a therapeutic approach in the treatment of inflammatory bowel disease? JR-N Lymphocytes that migrate to the […]

Network Meta-Analyses in Inflammatory Bowel Disease

G&H How does a network meta-analysis differ from a traditional meta-analysis? SS A traditional meta-analysis, also known as a pairwise or direct meta-analysis, compares treatments […]

Mucosal Healing in Crohn’s Disease and Ulcerative Colitis

G&H How has the definition of mucosal healing evolved? LP-B For many decades, mucosal healing equaled endoscopic healing. The main change is that, for several years […]

Clinical Implications of the Recent Dose-Ranging Studies of Adalimumab

G&H How was adalimumab dosing determined for the treatment of Crohn’s disease and ulcerative colitis? BF Currently, standard induction dosing is 160 mg initially, followed […]

Vedolizumab-Induced De Novo Extraintestinal Manifestations

Abstract: Background: Vedolizumab is an α4β7 integrin antagonist with gut-specific effects on lymphocyte and monocyte trafficking. Although the treatment is beneficial for inflammatory bowel disease (IBD), […]

Current Use of Fecal Calprotectin in the Management of Patients With Inflammatory Bowel Disease

G&H What is fecal calprotectin? MF Fecal calprotectin is a cytosolic component of neutrophils, which can be found in the intestinal bowel wall. When there […]

A Comprehensive Review of Topical Therapies for Distal Ulcerative Colitis

Abstract: Patients with ulcerative colitis (UC) limited to distal segments of the colon and rectum are often poorly represented in large clinical therapeutic trials, yet […]

The Current Role of Methotrexate in Patients With Inflammatory Bowel Disease

G&H What is the mechanism of action of methotrexate? JR Methotrexate has been used for a long time as a cancer treatment. When high doses […]

Etiology and Management of Lack or Loss of Response to Anti–Tumor Necrosis Factor Therapy in Patients With Inflammatory Bowel Disease

Abstract: The management of patients with moderate to severe inflammatory bowel disease was transformed with the arrival of anti–tumor necrosis factor (TNF) therapy. Nevertheless, a […]

Comparative Effectiveness Research in Inflammatory Bowel Disease: The VARSITY Study and Beyond

G&H What is comparative effectiveness research? BS Comparative effectiveness research refers to the comparison of health care interventions that already exist and is a way of […]

Serious and Opportunistic Infections in Elderly Patients With Inflammatory Bowel Disease

Abstract: Inflammatory bowel disease (IBD) is often treated with biologics and immunomodulators, which can place elderly IBD patients at risk for serious and opportunistic infections. […]

Restarting Biologic Agents After a Drug Holiday

G&H What are the most common reasons that patients with inflammatory bowel disease have a drug holiday from biologic therapy? DR The most common reasons […]