Pharmacologic Management of Nonalcoholic Steatohepatitis

Abstract: Nonalcoholic steatohepatitis (NASH) is increasingly recognized as a major form of chronic liver disease in adults and children. Although improved dietary habits and regular […]

Liver Transplantation for Alcoholic Liver Disease

G&H What is the standard treatment approach to alcoholic liver disease? EM The term alcoholic liver disease (ALD) comprises a spectrum of hepatic injury including […]

Overview of Current and Emerging Therapeutic Approaches to Nonalcoholic Steatohepatitis

G&H What role do diet and exercise play in the treatment of nonalcoholic steatohepatitis? SH Diet and exercise are the cornerstone of therapy for patients […]

Primary Sclerosing Cholangitis, Part 1: Epidemiology, Etiopathogenesis, Clinical Features, and Treatment

Abstract: Primary sclerosing cholangitis (PSC) is a chronic, idiopathic cholangiopathy that can progress to cirrhosis, end-stage liver disease, hepatobiliary cancer, and/or colorectal cancer. The course […]

Elimination of Hepatitis B and C Virus Infections

G&H Is it feasible to eliminate hepatitis B and C virus infections in the United States? AA Hepatitis B virus (HBV) and hepatitis C virus (HCV) […]

Novel Bile Acid Therapies for Liver Disease

G&H How were bile acids first used in a therapeutic role? SK Bile acids are a class of molecules that are involved in a variety […]

Emerging Therapeutic Targets for Hepatitis Delta Virus Infection

G&H How prevalent is hepatitis delta virus infection in the United States and worldwide? JG Estimates are that approximately 70,000 to 100,000 people in the United […]

Beta-Catenin Staining of Hepatocellular Adenomas

G&H How common are hepatocellular adenomas in the general population overall and among the various types of benign liver tumors? MG-B Hepatocellular adenomas have an […]

Practical Issues in the Management of Overt Hepatic Encephalopathy

Abstract: Hepatic encephalopathy (HE) is a condition that encompasses a range of neuropsychiatric abnormalities in patients with significant liver disease. Overt HE occurs in approximately […]

The Use of Nonselective Beta Blockers for Treatment of Portal Hypertension

G&H What are the various stages of portal hypertension? GG-T Portal hypertension, which simply refers to an increase in portal pressure, can occur in different […]

Management of Autoimmune Hepatitis in Pregnant Women

G&H What is autoimmune hepatitis, and how common is it in the general population? MP Autoimmune hepatitis (AIH) is an autoimmune disease of the liver […]

Treatment of Alcoholic Liver Disease

G&H What are the conditions that constitute alcoholic liver disease? TM Alcoholic liver disease has a broad clinical spectrum, from mild disease to severe, life-threatening […]

Diagnosis of Nonalcoholic Steatohepatitis Without Liver Biopsy

G&H What is the relationship between nonalcoholic steatohepatitis and nonalcoholic fatty liver disease, and how common are these conditions? BM Nonalcoholic fatty liver disease (NAFLD) […]

HBV/HCV Coinfection and Possible Reactivation of HBV Following DAA Use

G&H How does coinfection affect hepatitis B and C virus? Are the diseases more severe or resistant? RG When a person has active hepatitis B […]

Supplement-Induced Liver Injury

G&H How common is supplement-induced liver injury in the United States? VN That is a difficult question to answer because the true number of people […]

Bariatric Surgery and Liver Transplantation

Abstract: Obesity is an important public health and medical concern in the United States. The rate of obesity has steadily risen for the past several […]

Controversies in Liver Transplantation

Gastroenterology & Hepatology February 2017, Volume 13, Issue 2 James F. Trotter, MD Medical Director of Liver Transplantation Baylor University Medical Center Dallas, Texas G&H Should […]

Nonalcoholic Steatohepatitis and Endpoints in Clinical Trials

Abstract: Nonalcoholic fatty liver disease (NAFLD) is now the leading cause of liver disease in developed countries, and the rates of NAFLD continue to rise […]

Iron Overload in Patients With Chronic Liver Disease

G&H How common is iron overload in patients with chronic liver disease? KK Some degree of iron overload is present in anywhere from 10% to 30% […]

Practical Concerns and Controversies in the Management of Alcoholic Hepatitis

Gastroenterology & Hepatology Volume 12, Issue 8, August 2016 Gene Y. Im, MD, and Michael R. Lucey, MD Dr Im is an assistant professor of medicine […]