Eosinophils Beyond the Esophagus: A Review of Non-EoE Eosinophilic Gastrointestinal Diseases

Abstract: For eosinophilic esophagitis (EoE), the most well researched of the eosinophilic gastrointestinal diseases (EGIDs), there is a plethora of knowledge for its diagnosis and management; […]

Update on Organ Allocation and Liver Transplantation

Abstract: Liver transplantation remains a lifesaving intervention for patients with end-stage liver disease; however, organ demand continues to far exceed the supply. The core ethical principles […]

Irritable Bowel Syndrome in Inflammatory Bowel Disease Patients: Prevalence, Etiology, and Treatment

Abstract: One in 4 patients with endoscopically confirmed quiescent inflammatory bowel disease (IBD) reports persistent gastrointestinal symptoms, which are often compatible with irritable bowel syndrome (IBS). […]

New Approaches to Screening for Barrett Esophagus

Abstract: Current screening methods for Barrett esophagus (BE), the precursor to esophageal adenocarcinoma (EAC), are inadequate with less than one-third of screen-eligible patients currently undergoing screening. […]

From Past to Present: The Evolution of Pharmacologic Therapies for Eosinophilic Esophagitis

Abstract: Within the evolving landscape of eosinophilic esophagitis (EoE) management are multiple pharmacologic treatment modalities, including proton pump inhibitors (PPIs), swallowed topical corticosteroids, and novel biologic […]

Looking Toward the Future: Emerging Therapies for Hepatocellular Carcinoma

Abstract: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related deaths worldwide. Despite the decreasing prevalence of hepatitis C, the burden of HCC is expected to […]

Enhancing the Diagnostic Yield of EGD for Diagnosis of Barrett Esophagus Through Methylated DNA Biomarker Triage

Abstract: Background: EsoGuard (EG) is a methylated DNA assay for cells collected nonendoscopically with EsoCheck for detection of Barrett esophagus (BE) and can be utilized as […]

Overcoming Challenges in Electronic Health Record Use in Inflammatory Bowel Disease Care

Abstract: Electronic health record (EHR) systems were introduced to enhance patient data accessibility and improve care. However, in gastroenterology, particularly in the management of inflammatory bowel […]

The Evolving Role of Weight Loss Pharmacotherapy

Abstract: Obesity is a complex disease, afflicting millions of individuals worldwide. Multiple treatment options exist, including dietary and lifestyle modifications, pharmacotherapy, endobariatrics, and surgery. Although diet […]

Evolution of Therapy in Autoimmune Hepatitis

Abstract: Autoimmune hepatitis (AIH) is an immune-mediated liver disease characterized by a spectrum of clinical manifestations, ranging from asymptomatic liver enzyme abnormalities to fulminant liver failure. […]

Optimal Approach to Colorectal Cancer Screening

Abstract: Rates of colorectal cancer (CRC) screening in the United States continue to fall short of guideline-recommended benchmarks. Challenges to increasing CRC screening include racial disparities, […]

Complications of Metabolic and Bariatric Surgery for the Gastroenterologist: A Comprehensive Review

Abstract: By 2035, more than one-half of the global population is expected to have overweight or obesity, amounting to a substantial $4 trillion toll on the […]

Uncovering the Hidden Link Between the Aberrant Intestinal Microbiome and Fibromyalgia

Abstract: Fibromyalgia is a multifaceted syndrome primarily characterized by chronic widespread pain and fatigue. Despite its significant prevalence and incidence, the mechanisms mediating the disease pathogenesis […]

Approach to Meal-Related Nausea and Vomiting

Abstract: Nausea and vomiting are common symptoms that frequently lead to evaluation in the outpatient and inpatient settings. The pathophysiology of nausea and vomiting is complex, […]

Navigating Chronic Pouchitis: Pathogenesis, Diagnosis, and Management

Abstract: Chronic pouchitis affects 13% to 17% of patients with ileal pouch–anal anastomosis and ulcerative colitis, and 20% with a history of acute pouchitis. It is […]

Potassium-Competitive Acid Blockers and Proton Pump Inhibitors: The Dynamic Duo of Acid Blockers

Abstract: The management of acid-based disorders was transformed in the 1980s with the advent of proton pump inhibitors (PPIs), which target the hydrogen-potassium adenosine triphosphatase (proton […]

Management of Overweight and Obesity in Patients With Inflammatory Bowel Disease

Abstract: Increasing evidence has linked obesity to complications of inflammatory bowel disease (IBD); however, data are limited on the efficacy and impact of weight management strategies […]

Noninvasive Assessment to Identify Patients With At-Risk Metabolic Dysfunction-Associated Steatohepatitis

Abstract: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed nonalcoholic fatty liver disease, is a major global health issue and a leading cause of chronic liver […]

Alcohol Use Disorder and Alcohol-Associated Liver Disease: New Definitions, Screening, and Treatment

Abstract: Alcohol-associated liver disease (ALD) poses a significant global health burden and is a leading cause of liver-related morbidity and mortality. ALD encompasses a spectrum of […]

Rationale for an Eosinophilic Esophagitis Treat-to-Target Concept

Abstract: Eosinophilic esophagitis (EoE) is a chronic T helper 2–mediated inflammatory disorder of the esophagus defined clinically by the presence of symptoms of esophageal dysfunction and […]