Primary Sclerosing Cholangitis, Part 2: Cancer Risk, Prevention, and Surveillance

Abstract: Primary sclerosing cholangitis (PSC) is a chronic, fibroinflammatory, progressive cholangiopathy. In a clinically significant proportion of patients, the disease course of PSC is […]

Update on HCC Management and Review of the New EASL Guidelines

G&H How and when were the new European guidelines for hepatocellular carcinoma management developed? AA As part of its educational activities, the European Association for […]

Risk of Hepatocellular Carcinoma in Patients With Nonalcoholic Steatohepatitis

G&H How common are nonalcoholic steatohepatitis and hepatocellular carcinoma in the United States, and how often do they coexist in a patient? MC Fatty liver […]

Elastography and the Risk of Hepatocellular Carcinoma

G&H How can elastography be performed? JT The most common way to perform elastography, or measurement of the stiffness of a liver, is by using […]

Overview of the Updated AASLD Guidelines for the Management of HCC

G&H When will the new guidelines for hepatocellular carcinoma be released in print publication, and why was there a need for updated guidelines? JH The […]

Current Status of Sorafenib Use for Treatment of Hepatocellular Carcinoma

G&H What is the current understanding of the mechanism of action of sorafenib? HE-S Sorafenib (Nexavar, Bayer) is an orally administered, molecularly targeted medication for […]

Review of Regorafenib for the Treatment of Hepatocellular Carcinoma

G&H Why was there a need for a new hepatocellular carcinoma treatment before regorafenib? RF For the past 10 years, only 1 drug has shown […]

Advances and Future Directions in the Treatment of Hepatocellular Carcinoma

Abstract: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Liver transplant is considered the gold standard for curative therapy for HCC […]

The BALAD-2 and GALAD Biomarker Models for Hepatocellular Carcinoma

G&H Do biomarkers currently have a role in hepatocellular carcinoma? PJ The role of biomarkers in hepatocellular carcinoma (HCC) is controversial. For example, the best-known […]

The Role of Regorafenib in Hepatocellular Carcinoma

G&H What is the mechanism of action of regorafenib? CF The mechanism of action of regorafenib (Stivarga, Bayer) is very similar to that of sorafenib […]

Liver Transplant and Hepatocellular Carcinoma

G&H How are donor livers currently allocated to patients in need of a transplant? RW The current allocation system for patients with chronic liver disease […]

The Role of Liver Biopsy in Hepatocellular Carcinoma

Gastroenterology & Hepatology October 2016, Volume 12, Issue 10 Richard S. Finn, MD Associate Professor of Medicine Department of Medicine Division of Hematology/Oncology Geffen School of […]