Durvalumab Plus Tremelimumab for First-Line Treatment of Hepatocellular Carcinoma

G&H What is the rationale for using durvalumab and tremelimumab in combination for the treatment of hepatocellular carcinoma? RK Durvalumab (Imfinzi, AstraZeneca) and tremelimumab (Imjudo, AstraZeneca) […]

Current Status of Hepatocellular Carcinoma Surveillance

G&H  What evidence is currently available showing the benefits of hepatocellular carcinoma surveillance?  NP  The benefits of hepatocellular carcinoma (HCC) surveillance have been evaluated in several […]

Selective Internal Radiation Therapy Using Yttrium-90 in Early and Intermediate Hepatocellular Carcinoma

G&H  How does selective internal radiation therapy using yttrium-90 work? RS  Selective internal radiation therapy (SIRT), also known as radioembolization, involves the intra-arterial injection of micron-sized […]

Hepatocellular Carcinoma and Hepatitis Delta Virus

G&H  Is hepatitis delta virus oncogenic? NR  The simple answer is yes, although hepatitis delta virus (HDV) is not yet labeled as a carcinogenic virus. It […]

How to Choose Second-Line Treatment for Hepatocellular Carcinoma

G&H  What are the current options for first-line medical treatment of hepatocellular carcinoma? CF Recently, there has been a significant progression in the options that are […]

Smoking and Liver Disease

  Abstract: Cigarette smoking is the leading cause of preventable disease and death in the United States, causing approximately 480,000 deaths per year, which is equivalent […]

Update on the Diagnosis and Treatment of Hepatocellular Carcinoma

  Abstract: Hepatocellular carcinoma (HCC) is the fourth-leading cause of cancer-related mortality worldwide and the fastest-rising cause of cancer-related death in the United States. Given the […]

Risk of Hepatocellular Carcinoma Using Tenofovir Disoproxil Fumarate Vs Entecavir for Hepatitis B Virus Treatment 

  G&H  What is the current understanding of the relationship between hepatocellular carcinoma and hepatitis B virus infection?  RW  Patients infected with chronic hepatitis B virus […]

Current Status of the Use of Statins and Aspirin in the Chemoprevention of Hepatocellular Carcinoma

  G&H  What are the main risk factors for hepatocellular carcinoma? YH  Hepatocellular carcinoma (HCC) almost exclusively develops from underlying chronic liver disease, which is characterized […]

Atezolizumab and Bevacizumab Combination Therapy for Hepatocellular Carcinoma

  G&H  What are the current first-line medical treatment options for hepatocellular carcinoma? AE-K  Two drugs have been approved for the first-line treatment of hepatocellular carcinoma […]

Current Status of the GALAD and BALAD Biomarker Models for Hepatocellular Carcinoma

  G&H  How has the role of biomarkers evolved in hepatocellular carcinoma? LR  Perhaps the most common way that biomarkers are being used is to aid […]

Overview of Ablative Therapy for Hepatocellular Carcinoma

  G&H  What is the role of radiofrequency ablation and microwave ablation in the treatment of hepatocellular carcinoma? SR  Both radiofrequency ablation and microwave ablation are […]

The Gastroenterologist’s Guide to Preventive Management of Compensated Cirrhosis

  Abstract: Despite advances in medical care, the prevalence and mortality associated with cirrhosis continue to rise. The majority of medical care and physician efforts are […]

Current and Future Systemic Therapies for Hepatocellular Carcinoma

  Abstract: Hepatocellular carcinoma (HCC) is a common cancer with unmet needs and limited effective therapeutic options. The management strategy for diagnosed HCC is based on […]

Statins and Hepatocellular Carcinoma Protection

G&H  What have studies found regarding the possible relationship between statins and hepatocellular carcinoma protection?  DK  Approximately 10 years ago, the first large study looking at […]

Care of Patients Following Cure of Hepatitis C Virus Infection

  Abstract: The vast majority of persons with chronic hepatitis C virus (HCV) infection will achieve virologic cure with the current direct-acting antiviral therapies. Prevention of […]

Treatment of Hepatocellular Carcinoma With Lenvatinib

  G&H  What is the mechanism of action of lenvatinib?  K-HH  Lenvatinib (Lenvima, Eisai) is a tyrosine kinase inhibitor selectively targeting vascular endothelial growth factor receptor […]

Drugs in Development for Hepatocellular Carcinoma 

  G&H  What have been the most recent advances or changes in hepatocellular carcinoma drug development? LR  For approximately 10 years, the only drug available for […]

Gastro-Hep News

US Food and Drug Administration Approves Lenvatinib for Hepatocellular Carcinoma On August 16, 2018, the US Food and Drug Administration (FDA) approved the kinase inhibitor lenvatinib […]

Primary Sclerosing Cholangitis, Part 2: Cancer Risk, Prevention, and Surveillance

    Abstract: Primary sclerosing cholangitis (PSC) is a chronic, fibroinflammatory, progressive cholangiopathy. In a clinically significant proportion of patients, the disease course of PSC is […]

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