Introduction to Biosimilar Use in Patients With Inflammatory Bowel Disease 

  G&H  What is a biosimilar? GL  According to the US Food and Drug Administration (FDA), a biosimilar is a product that is highly similar to […]

Overview of Therapeutic Drug Monitoring of Biologic Agents in Patients With Inflammatory Bowel Disease

  G&H  What is the goal of therapeutic drug monitoring? AC  From my perspective, the goal of therapeutic drug monitoring (TDM) is to optimize the care […]

When Not to Pouch: Important Considerations for Patient Selection for Ileal Pouch–Anal Anastomosis

  Abstract: Ileal pouch–anal anastomosis (IPAA) is the preferred surgical treatment for patients who undergo colectomy and wish to avoid a permanent ileostomy. The overall outcomes […]

Health Maintenance Assessment for Patients With Inflammatory Bowel Disease

  G&H  Why is health maintenance assessment important in patients with inflammatory bowel disease? SK  Many patients with inflammatory bowel disease (IBD) are relatively young (ie, […]

Vaccination of Patients With Inflammatory Bowel Disease

  G&H  How does the vaccination rate in patients with inflammatory bowel disease compare with that of the general population? FF  Vaccination rates in patients with […]

Advances in the Diagnosis and Management of Colonic Dysplasia in Patients With Inflammatory Bowel Disease

  Abstract: The prevalence of colorectal cancer (CRC) in inflammatory bowel disease (IBD) is estimated at 3.7%. Risk factors for CRC include more severe disease (as […]

The Role of Chromoendoscopy in Evaluating Colorectal Dysplasia

  Abstract: Chromoendoscopy pertains to image-enhanced endoscopic techniques such as dye-based chromoendoscopy and electronic chromoendoscopy using narrow-band imaging, flexible spectral imaging color enhancement, and i-scan. Dye-based […]

Medical Homes for Patients With Inflammatory Bowel Disease

  G&H  Why is there a need for a new model of care for patients with inflammatory bowel disease? MR  A new model of patient care […]

Combination Therapy for Inflammatory Bowel Disease

  G&H  What are the traditional treatment strategies for inflammatory bowel disease, and where does combination therapy fit among them? SH  The current algorithms for treating […]

Fecal Microbiota Transplantation: From Clostridium difficile to Inflammatory Bowel Disease

  Abstract: Fecal microbiota transplantation (FMT) has evolved from a case report in the medical literature to the basis of major innovations in the treatment of […]

Common Chronic Complications Following Inflammatory Bowel Disease Surgery

  G&H  What are the most common surgeries performed for the treatment of inflammatory bowel disease? SS  The most common operations for Crohn’s disease are resection, […]

Considering the Bidirectional Pathways Between Depression and IBD: Recommendations for Comprehensive IBD Care

  Abstract: Because of disease chronicity and required shifts in coping and self-management skills over time, it is not surprising that patients with inflammatory bowel disease […]

Management of Hospitalized Patients With Ulcerative Colitis

  G&H  What are the indications for hospitalization of patients with ulcerative colitis? LB  Patients with ulcerative colitis (UC) who have failed or have not responded […]

Reversal of Immunogenicity in Inflammatory Bowel Disease

  G&H  Why does immunogenicity occur in patients with inflammatory bowel disease? SB-H  This is a complex issue. Immunogenicity refers to the propensity of biologic drugs […]

The Use of Fecal Calprotectin in Inflammatory Bowel Disease

G&H  What is fecal calprotectin? IB  Calprotectin is a calcium- and zinc-binding protein, which for practical purposes can be considered to be neutrophil-specific, although low levels […]

The Role of Biosimilars in Inflammatory Bowel Disease

  Abstract: Monoclonal antibody biologic therapies, introduced nearly 20 years ago, revolutionized the treatment of inflammatory bowel disease (IBD) and are now well established as the […]

Inhibition of Interleukin-12 and/or -23 for the Treatment of Inflammatory Bowel Disease

  G&H  Which agents have been evaluated for inhibiting interleukin-12 and/or -23 for the treatment of inflammatory bowel disease? BS  A handful of agents have been, […]

Therapeutic Use of Cannabis in Inflammatory Bowel Disease

Abstract: The marijuana plant Cannabis sativa and its derivatives, cannabinoids, have grown increasingly popular as a potential therapy for inflammatory bowel disease (IBD). Studies have shown […]

Update on the Incidence and Prevalence of Inflammatory Bowel Disease in the United States

G&H  What is the current incidence of Crohn’s disease in the United States? EL  This question is surprisingly complicated to answer because the incidence likely varies […]

Stem Cell Therapy for Perianal Fistulas in Crohn’s Disease

G&H  How common are perianal fistulas in Crohn’s disease, and how effective is standard medical therapy? JP  Perianal fistulas affect up to 40% of patients diagnosed […]

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