Current Status of Sorafenib Use for Treatment of Hepatocellular Carcinoma 

  G&H  What is the current understanding of the mechanism of action of sorafenib? HE-S  Sorafenib (Nexavar, Bayer) is an orally administered, molecularly targeted medication for […]

Review of Regorafenib for the Treatment of Hepatocellular Carcinoma

  G&H  Why was there a need for a new hepatocellular carcinoma treatment before regorafenib? RF  For the past 10 years, only 1 drug has shown […]

Advances and Future Directions in the Treatment of Hepatocellular Carcinoma

  Abstract: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Liver transplant is considered the gold standard for curative therapy for HCC […]

Occurrence and Recurrence of Hepatocellular Carcinoma After Successful Direct-Acting Antiviral Therapy for Patients With Chronic Hepatitis C Virus Infection

  Abstract: Chronic hepatitis C virus (HCV) infection has generally been associated with a slightly increased risk of developing hepatocellular carcinoma (HCC). For the past several […]

Use of the Liver Imaging Reporting and Data System in Hepatocellular Carcinoma

  G&H  Why was the Liver Imaging Reporting and Data System created? CS  A colleague and I decided to create the Liver Imaging Reporting and Data […]

The BALAD-2 and GALAD Biomarker Models for Hepatocellular Carcinoma

  G&H  Do biomarkers currently have a role in hepatocellular carcinoma? PJ  The role of biomarkers in hepatocellular carcinoma (HCC) is controversial. For example, the best-known […]

The Role of Regorafenib in Hepatocellular Carcinoma

  G&H  What is the mechanism of action of regorafenib? CF  The mechanism of action of regorafenib (Stivarga, Bayer) is very similar to that of sorafenib […]

Liver Transplant and Hepatocellular Carcinoma

  G&H  How are donor livers currently allocated to patients in need of a transplant? RW  The current allocation system for patients with chronic liver disease […]

Biomarkers for Hepatocellular Carcinoma

G&H  How has the diagnostic role of alpha-fetoprotein changed over time? LR When hepatocellular carcinoma (HCC) was first recognized as a distinct disorder of cancer in […]

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